Enzymatically active recombinant glucocerebrosidase

Details Enzymatically active recombinant glucocerebrosidase Enzymatically active recombinant glucocerebrosidase

1991-08-21

1993-08-17

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 691, 435 698, 435 703, 435 701, 4351723, 4352402, 4353201, 536 232, 935 14, 935 27, 935 34, 935 50, 935 70, 935 66, C12N 942, C12N 1556, C12N 1585

Patent

active

052368386

ABSTRACT:
Recombinant enzymatically active glucocerebrosidase is produced by a eukaryotic cell. Also, a cell includes nucleic acid encoding enzymatically active glucocerebrosidase; also a eukaryotic organism contains such a cell. Also, a method for producing enzymatically active glucocerebrosidase includes steps of introducing glucocerebrosidase-encoding nucleic acid into a eukaryotic cell, causing the cell to express glucocerebrosidase, and purifying the glucocerebrosidase from the cell.

REFERENCES:
patent: 4675285 (1987-06-01), Clark et al.
patent: 4713339 (1987-12-01), Levinson et al.
patent: 4727138 (1988-02-01), Goeddel et al.
Martin, B. et al. "Glycosylation and Processing of High Levels of Active . . . " DNA 7(2):99-106 (Mar. 1988).
Sorge, J. et al. "Complete Correction of the Enzymatic Defect of Type I . . . " Proc. Natl. Acad. Sci USA 84 pp. 906-909 (Feb. 1987).
Choudary S. et al, "The Molecular Biology of Gaucher Disease . . . " Cold Spring Harbor Symposia on Quantitative Biology vol. LI:1047-1052 (1986).
Maeda, S. "Production of Human .alpha.-Interferon in Silkworm . . . " Nature vol. 315:592-594 (Jun. 1985).

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