Enzymatic treatment of retinitis pigmentosis

Details Enzymatic treatment of retinitis pigmentosis Enzymatic treatment of retinitis pigmentosis

2002-10-01

2008-11-04

Hobbs, Lisa J (Department: 1657)

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Stabilized enzymes or enzymes complexed with nonenzyme

C424S094100, C424S427000, C435S006120

Reexamination Certificate

active

07445777

ABSTRACT:
A pharmaceutical kit for treatment of retinitis pigmentosis and a method of producing the same, the kit comprising the enzymes glutathione peroxidase, prolidase, glucose-6-phosephate dehydrogenase and, optionally, aldose reductase in aliquot parts and interactive quantities appropriate for administering the enzymes in accordance with a predetermined time sequence.

REFERENCES:
patent: 2784030 (2000-04-01), None
patent: 2784898 (2000-04-01), None
Carmody et al. (1999) Reactive Oxygen Species as Mediators of Photoreceptor Apoptosis in Vitro. Experimental Cell Research 248(2): 520-530.
Ahuja-Jensen et al. (2007) Low glutathione peroxidase in rdl mouse retina increases oxidative stress and proteases. NeuroReport 18(8): 797-801.
Ling-Hua Zeng et al., “Genetic Study of Retinitis Pigmentosa in China”,Ophthalmologica,vol. 194, No. 1, 1987, pp. 34-39.
E.M. Gloria et al., “The Pathogenesis of Retinitis Pigmentosa. A Pilot Study on the Clinical Fluoroangiographic and Enzymatic Effect of Bendazac Lysine”,Bollettino di Oculistica,vol. 69, No. 2, 1990, pp. 309-318.

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