Enzymatic transformation of a prostaglandin (bimatoprost)...

Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...

Reexamination Certificate

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C435S198000

Reexamination Certificate

active

07611886

ABSTRACT:
A method for the selective enzymatic acetylation of a bimatoprost intermediate is provided.

REFERENCES:
patent: 3969396 (1976-07-01), Yankee
patent: 0 501 310 (1992-02-01), None
patent: WO 91/04337 (1999-04-01), None
patent: WO 01/55101 (2001-08-01), None
Corey, J.A.C.S., 1969, pp. 5675, vol. 91.
Resul, et al., “Phenyl-Substituted Prostaglandins: Potent And Selective Antiglaucoma Agents”,J. Med. Chem., 1993, pp. 243-248, vol. 36.
Fox et al., “An Enantioconvergent Synthesis of (R)-4-Aryloxy-1-butyne-3-ols for Prostanoid Side Chains”, Adv. Synth. Catel. (344) 50-56 (2000).
Taber et al., “Total Synthesis of the Four Enantiomerically Pure Diastereomers of 8-F2rIsoprostane”, J. Org. Chem. (66) 1876-1884(2001).
Chen et al., “Preparation of optically Active Tertiary Alcohols by Enzymatic Methods. Application to the Synthesis of Drugs and natural Products”, J. Org. Chem. (62) 4349- 4357 (1997).
English Translation of Office Action for Application, JP2007-511732, pp. 1-7, not fully considered due to lack of documents therein.

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