Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving oxidoreductase
Patent
1987-10-23
1989-05-02
Yasich, Daniel M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving oxidoreductase
435,25, 435810, 426 88, 374106, 374160, 116207, 116217, C12Q 128, G01K 1106
Patent
active
048267627
ABSTRACT:
A temperature change indicator is described which is composed of an enzyme and a substrate for that enzyme suspended in a solid organic solvent or mixture of solvents as a support medium. The organic solvent or solvents are chosen so as to melt at a specific temperature or in a specific temperature range. When the temperature of the indicator is elevated above the chosen, or critical temperature, the solid organic solvent support will melt, and the enzymatic reaction will occur, producing a visually detectable product which is stable to further temperature variation.
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patent: 3956153 (1976-05-01), Chadha
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patent: 4579823 (1986-04-01), Ryder
patent: 4716101 (1987-12-01), Thompson et al.
patent: 4740465 (1988-04-01), Suzuki
Boeriu et al., BioTechn., "Enzymatic Reactions in Liquid and Solid Paraffins: Application for Enzyme-Based Temperature Abuse Sensors", 4 (11/86), 2 pages.
Dordick Jonathan S.
Klibanov Alexander M.
Massachusetts Industry of Technology
Yasich Daniel M.
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