Enzymatic synthesis of .beta.-lactam antibacterials

Details Enzymatic synthesis of .beta.-lactam antibacterials Enzymatic synthesis of .beta.-lactam antibacterials

1980-09-19

1982-07-20

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-4-aza-bicyclo

435 50, C12P 3704

Patent

active

043406726

ABSTRACT:
Penicillins and cephalosporins can be synthesized by the action of an acylase on a penicillin or cephalosporin nucleus amine as substrate and an ester (I) of the following formula as the acyl source: ##STR1## (wherein RCO is an acyl group in penicillin or cephalosporin side chains;

REFERENCES:
patent: 3787288 (1974-01-01), Miyamura et al.
patent: 3945888 (1976-03-01), Takahashi et al.
patent: 4073687 (1978-02-01), Kondo et al.

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