Enzymatic synthesis of alpha-L-aspartyl-L-phenyalanine lower alk

Details Enzymatic synthesis of alpha-L-aspartyl-L-phenyalanine lower alk Enzymatic synthesis of alpha-L-aspartyl-L-phenyalanine lower alk

1989-05-04

1991-10-08

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

560 40, C12P 2100, C07C22900

Patent

active

050553992

ABSTRACT:
Enzyme-catalyzed synthetic reactions having otherwise unfavorable equilibria are facilitated by recovery of polypeptides by electrodialysis. A process of preparing polypeptides is provided that can be operated continuously to produce high yields of enriched polypeptides without recourse to post-synthetic product manipulations heretofore employed that are expensive and present a risk of residual toxic by-products. The invention is applied to advantage in the preparation of alpha-L-aspartyl-L-phenylalanine lower alkyl esters.

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