Enzymatic RNA molecules that cleave mutant N-RAS

Details Enzymatic RNA molecules that cleave mutant N-RAS Enzymatic RNA molecules that cleave mutant N-RAS

1997-05-23

2000-03-14

Brusca, John S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435375, C07H 2100

Patent

active

060374632

ABSTRACT:
Enzymatic RNA molecules have been designed that cleave mutant N-ras mRNA, preferably at a NUX cleavage site (N=any base, X=A, C or U). Preferred ribozymes have nucleotide sequences 5'-CCAACACCUGAUGAGCGUUAGCGAAACCUGCU-3' or 5'-UCCCAACCUGAUGAGCGUUAGCGAAACACCUG-3' (SEQ ID NOS:1 and 2), and derivatives thereof. The present invention also provides pharmaceuticals containing such molecules and the use of such molecules for the preparation of pharmaceuticals for the treatment of diseases involving abnormal cell growth and/or differentiation.

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