Enzymatic resolution process hydrolyzing thio-ester

Details Enzymatic resolution process hydrolyzing thio-ester Enzymatic resolution process hydrolyzing thio-ester

1989-10-25

1992-07-07

Rosen, Sam

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435135, C12P 762

Patent

active

051282631

ABSTRACT:
A novel enzymatic resolution process for preparing resolved compounds of the formula ##STR1## with improved yields and high optical purity is disclosed. The thioester bond of the compound is hydrolyzed and the hydrolyzed compound is separated from the unhydrolyzed. Compounds of formula I' are useful, for example, as intermediates for the preparation of physiologically active compounds, e.g. captopril and zofenopril.

REFERENCES:
patent: 4629701 (1986-12-01), Sakimae et al.

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