Enzymatic resolution of t-butyl taxane derivatives

Details Enzymatic resolution of t-butyl taxane derivatives Enzymatic resolution of t-butyl taxane derivatives

2006-06-20

2006-06-20

Marx, Irene (Department: 1651)

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

C549S510000, C549S511000, C549S357000, C435S123000, C435S117000, C435S197000

Reexamination Certificate

active

07063977

ABSTRACT:
A method for the resolution of a mixture of the cis or trans enantiomers of a compound of the formulawherein R1is —O—C(O)alkyl, —O—C(O)aryl or —O—C(O)cycloalkyl by contacting the mixture with a carboxylic ester hydrolase enzyme which catalyzes the stereoselective hydrolysis of the mixture and the use of such enantiomers to produce antitumor compounds which are especially suitable for oral administration.

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