Enzymatic resolution of substituted 2-methyl-propionic acid

Details Enzymatic resolution of substituted 2-methyl-propionic acid Enzymatic resolution of substituted 2-methyl-propionic acid

1994-02-18

1995-12-19

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560 61, 560102, 560105, C07B 5500

Patent

active

054769655

ABSTRACT:
Provided are enzymatic methods for the selective hydrolytic resolution of certain enantiomers of a pharmaceutical compound, the pharmaceutical compound comprising a (.+-.) mixture of a .alpha.-substituted 2-methyl proprionic acid derivative. Specifically provided is the selective enzymatic resolution of either the R(+) or S(-) enantiomer of (.+-.)-ethyl ciprofibrate. Also provided are substantially pure enantiomers of R(+) and S(-) ciprofibrate.

REFERENCES:
CA 112 (15):137568s 1989.
CA 115 (17):182683y 1991.
CA 120 (2):22822t 1993.
CA 118 (25):254492x 1993.

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