Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing nitrogen-containing organic compound
Patent
1996-07-23
2000-10-03
Jordan, Charles T.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing nitrogen-containing organic compound
435280, 435822, C12P 1302, C07C 104, C12N 100
Patent
active
H00018937
ABSTRACT:
An enzymatic reduction method, particularly a stereoselective enzymatic reduction method, for the preparation of halohydrins from haloketones. The halohydrin products are particularly useful in the preparation of epoxides, which may be employed as intermediates in the preparation of protease inhibitors such as retroviral protease inhibitors.
REFERENCES:
patent: 5481011 (1996-01-01), Chen et al.
Christen M. et al., Biotransformation in Organic Synthesis: Applications of Yeast Reduction in the Synthesis of 3,5-Dihydroxy Esters of High Optical Plurity, J. Chem. Soc. Chem. Comm. 1988: 264-266.
Banerjee Amit
McNamee Clyde G.
Patel Ramesh N.
Szarka Laszlo J.
Babajko Suzanne E.
Baker Aileen J.
Bristol--Myers Squibb Company
Jordan Charles T.
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