Enzymatic process for the preparation of rosmarinic acid

Details Enzymatic process for the preparation of rosmarinic acid Enzymatic process for the preparation of rosmarinic acid

1989-12-13

1991-04-30

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435146, 435147, 435190, C12P 740, C12P 756, C12P 762, C07C 69732

Patent

active

050117750

ABSTRACT:
A process is disclosed for the production of rosmarinic acid of the formula ##STR1## by enzymatic reaction of 3-(3,4-dihydroxyphenyl)-lactic acid with caffeoyl-coenzyme A in the presence of rosmarinic acid synthase. Ketodopa, which is readily accessible from dopa, is used as the starting material and caffeoyl-CoA is preferably regenerated by addition of caffeic acid.

REFERENCES:
Petersen et al., "Two New Enzymes of Rosmarinic Acid Biosynthesis from Cell Cultures of Coleus blumei: Hydroxyphenylpyruvate Reductase and Rosmarinic Acid Synthase", Z. Naturforsch. 43 c: (1988) pp. 501-504.
Derwent Biotech Abs. 84-11669 De-Eknamkul et al., PLMEAA "Planta Med" (1984) 50, 4, 346-50.
Derwent Biotech Abs 86-09512 Ellis "Primary Secondary Metab Plant Cell Culture" (1985) 164-173.
Derwent Abs. 84-171729/29 DE3247610 (7-1984) Ulbricht et al.

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