Enzymatic process for making morphine-6-glucuronide or substitut

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing nitrogen-containing organic compound

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435200, C12P 1300, C12N 924

Patent

active

057503818

ABSTRACT:
A method of making morphine-6-glucuronide comprising the selective enzymatic cleavage of the 3-glucuronide moiety in morphine-3, 6-glucuronide or substituted morphine-6-glucuronide using at least one .beta.-glucuronide.

REFERENCES:
Brown et al., Sybthesis of morphine-6-glucuronide via a highly selective catalysed hydrolysis reaction, Tetrahedron Letters, vol. 36(7), pp. 1117-1120, Feb. 13, 1995.

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