Enzymatic preparation of optically active propanolol and .beta.-

Details Enzymatic preparation of optically active propanolol and .beta.- Enzymatic preparation of optically active propanolol and .beta.-

1992-04-15

1994-08-02

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

C12P 4100

Patent

active

053345347

ABSTRACT:
A computer modeling approach is taken to delineate the structural requirements of substrate molecules for biocatalytic turnover and enantioselective discrimination. This leads to an efficient enzymatic preparation of optically active propranolol. The acyl-sustituents on the alcohol and the secondary amine of propranolol play crucial roles in controlling the catalysis and enantiospecificity, respectively, of the enzymatic hydrolysis.

REFERENCES:
Shieh W., JCS Chem Comm. 9:651-3 (1991).
Sagai T., J. Org Chem. 55:4643-47 (1990).
Sonnet P., Lipids 26:295-300 (1991).

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