Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Patent
1995-09-08
1997-01-14
Rollins, John W.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
435921, C12P 724
Patent
active
055938728
ABSTRACT:
A process for the enzymatic oxidation of alcohols to aldehydes in a continuous reaction series is disclosed utilizing crude cellular methanol oxidase and catalase produced by an acceptable organism. The process maintains a steady-state aldehyde concentration whereby enzyme activity is promoted and side reactions are eliminated.
In particular, the process has two reactors operating in series continuously producing a fermenter effluent containing growing, intact Candida boidinii cells at a cell concentration of about 0.5 to about 3% by weight of the effluent by continuous culture of the cells on a methanol carbon source, continuously introducing the effluent from the first reactor to the second reactor, adding an alcohol feed at about 0.2-10% w/w and oxygen to the second reactor, maintaining a steady-state aldehyde and alcohol concentration in the reaction mixture, the concentration of residual alcohol being about 0.1-9% w/w by controlling the rates of introduction of effluent and alcohol feed.
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Gabelman Alan
Luzio Gary A.
Rollins John W.
Saucier S.
Tastemaker
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