Enzymatic nucleic acid molecules

Details Enzymatic nucleic acid molecules Enzymatic nucleic acid molecules

2006-11-28

2010-10-05

Vivlemore, Tracy (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C514S04400A, C536S023100

Reexamination Certificate

active

07807817

ABSTRACT:
The present invention discloses nucleic acid enzymes and deoxyribonucleic acid enzymes capable of cleaving nucleic acid sequences or molecules, particularly RNA, in a site-specific manner, as well as compositions including same. Methods of making and using the disclosed enzymes and compositions are also disclosed.

REFERENCES:
patent: 5861288 (1999-01-01), Usman et al.
patent: 5879938 (1999-03-01), Usman et al.
patent: 5998203 (1999-12-01), Matulic-Adamic et al.
patent: 6008343 (1999-12-01), Jennings et al.
patent: 6159714 (2000-12-01), Usman et al.
patent: WO95/11304 (1995-04-01), None
Breaker, DNA enzymes, 1997,Nature Biotech.,15:427-431.
Beaudry and Joyce, “Directed Evolutionof an RNA Enzyme”,Science,257:635-641 (1992).
Breaker, et al., “Continuous in Vitro Evolution of Bacteriophage RNA Polymerase Promoters”,Biochemistry,33:11980-11986 (1994).
Breaker and Joyce, “Inventing and Improving Ribozyme Function: Rational Design Versus Iterative Selection Methods”,Trends Biotech,12:268-275 (1994).
Breaker and Joyce, “A DNA Enzyme with Mg2+-Dependent RNA Phosphoesterase Activity”,Chemistry&Biology,2:655-660 (1995).
Burgstaller and Famulok, “Synthetic Ribozymes and the First Deoxyribozyme”,Angew. Chem. Int. Ed. Engl.,34:1189-1192 (1995).
Cadwell and Joyce, “Randomization of Genes by PCR Mutagenesis”,PCR Methods and Applications,2:28-33 (1992).
Cadwell and Joyce, “Mutagenic PCR”,PCR Methods and Applications,3(Suppl): s136-s140 (1994).
Chartrand, et al., “A Oligodeoxyribonucleotide with Catalytic Properties”,Proc. RNA Society,(1994) Abstract.
Joyce and Inoue, “A Novel Technique for the Rapid Preparation of Mutant RNAs”,Nucleic Acids Research,17:711-722 (1989).
Joyce, “Amplification, Mutation and Selection of Catalytic RNA”,Gene,82:83-87 (1989).
Joyce, “In Vitro Evolution of Nucleic Acids”,Current Opinion in Structural Biology,4:331-336 (1994).
Lehman and Joyce, “Evolution In Vitro of an RNA Enzyme with Altered Metal Dependence”,Nature,361:182-185 (1993).
Pan and Uhlenbeck, “In Vitro Selection of RNAs that Undergo Autolytic Cleavage with Pb2+”,Biochemistry,31:3887-3895 (1992).
Pan and Uhlenbeck, “A Small Metalloribozyme with a Two-Step Mechanism”,Nature,358:560-563 (1992).
Paquette, et al., “The Conformation of Single-Stranded Nucleic Acids tDNA Versus tRNA”.Eur. J. Biochem.,189:259-265 (1990).
Perreault, et al., “Mixed Deoxyribo- and Ribo-oligonucleotides with Catalytic Activity”,Nature,344:565-567 (1990).
Robertson and Joyce, “Selection In Vitro of an RNA Enzyme that Specifically Cleaves Single-Stranded DNA”,Nature,344:467-468 (1990).
Tsang and Joyce, “Evolutionary Optimization of the Catalytic Properties of a DNA-Cleaving Ribozyme”,Biochemistry,33:5966-5973 (1994).
Williams, et al., “Function of Specific 2′-Hydroxyl Groups of Guanosines in a Hammerhead Ribozyme Probed by 2′ Modifications”,Proc. Natl. Acad. Sci., USA,89:918-921 (1992).
Yang, et al., “Minimum Ribonucleotide Requirement for Catalysis by the RNA Hammerhead Domain”,Biochemistry,31:5005-5009 (1992).

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