Enzymatic measurement of mycophenolic acid

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving oxidoreductase

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 4, 435975, 514374, C12Q 126, C12Q 100

Patent

active

061070521

ABSTRACT:
The present invention provides a method for the enzymatic measurement of mycophenolic acid and other IMPDH inhibitors in biological samples.
The present invention also provides assay reagents and packaged kits useful for performing enzymatic measurement of mycophenolic acid and other IMPDH inhibitors in biological samples.

REFERENCES:
patent: 4753935 (1988-06-01), Nelson et al.
patent: 5380879 (1995-01-01), Sjogren
patent: 5444072 (1995-08-01), Patterson et al.
patent: 5665583 (1997-09-01), Collart et al.
patent: 5807876 (1998-09-01), Armistead et al.
Fleming et al; "Biochemistry", V.35(22), p 6990-6997, Jun. 4, 1996.
Anderson, J. H., et al., "Inosinic Acid Dehydrogenase of Sarcoma 180 Cells," The Journal of Biological Chemistry 243 (18) 4762-4768 (1968).
Babson, A. L., et al., "Kenetic Colorimetric Measurement of Serum Lactate Dehydrogenase Activity," Clinical Chemistry 19 (7): 766-769 (1973).
Beal, J. L., et al., "Evaluation of an Immunoassay (EMIT) for Mycophenolic Acid in Plasma From Renal Transplant Recipients Compared With a High-Performance Liquid Chromatography Assay," Therapeutic Drug Monitoring 20:685-690 (1998).
Carr, S. J., et al., "Characterization of Human Type I and Type II IMP Dehydrogenases," The Journal of Biological Chemistry 268 (36):27286-27290 (1993).
Collart, F. R., et al., "Cloning and Sequence Analysis of the Human and Chinese Hamster Inosine-5'-monophosphate Dehydrogenase cDNAs," The Journal of Biological Chemistry 263 (30):15769-15772 (1988).
Emit(TM) Mycophenolic Acid Assay package insert, Behring Diagnostics Inc., San Jose, CA (1996).
Epinette, W. W., et al., "Mycophenolic acid for psoriasis," Journal of the American Academy of Dermatology 17 (6):962-971 (1987).
Fleming, M. A., "Inhibition of IMPDH by Mycophenolic Acid: Dissection of Forward and Reverse Pathways Using Capillary Electrophoresis," Biochemistry 35:6990-6997 (1996).
Glesne, D. A., et al., "Cloning and Sequence of the Human Type II IMP Dehydrogenase Gene," Biochem. Biophys. Res. Commun. 205 (1):537-544 (1994).
Griesmacher, A., et al., "Inhibition of Inosine Monophosphate Dehydrogenase Activity by the Plasma of Heart Transplant Recipients Receiving Mycophenolate Mofetil," Ludwig Boltzmann Institute for Cardiosurgical Research at the Institute of Laboratory Diagnostics of the Kaiser-Franz-Josef-Hospital 104:537-541 (1998).
Hager, P. W., et al., "Recombinant Human Inosine Monophosphate Dehydrogenase Type I and Type II Proteins," Biochemical Pharmacology 49 (9):1323-1329 (1995).
Jones, C. E., et al., "High-performance liquid chromatography determination of mycophenolic acid and its glucuronide metabolite in human plasma," Journal of Chromatography B 708:229-234 (1998).
Jones, D. F. et al., "Microbial Modification of Mycophenolic Acid," J. Chem. Soc. (C):1725-1737 (1970).
Konno, Y., et al., "Expression of Human IMP Dehydrogenase Types I and II in Escherichia coli and Distribution in Human Normal Lymphocytes and Leukemic Cell Lines," The Journal of Biological Chemistry 266 (1):506-509 (1991).
Langman, L. J., et al., "Blood Distribution of Mycophenolic Acid," Therapeutic Drug Monitoring 16:602-607 (1994).
Lee, W. A., "Bioavailability Improvement of Mycophenolic Acid Through Amino Ester Derivatization," Pharmaceutical Research 7 (2):161-166 (1990).
Magasanik, B., et al., "Enzymes Essential for the Biosynthesis of Nucleic Acid Guanine; Inosine 5'-Phosphate Dehydrogenase of Aerobacter Aerogenes," J. Biol. Chem. 226:339-350(1957).
Natsumeda, Y., et al., "Two Distinct cDNAs for Human IMP Dehydrogenase," The Journal of Biological Chemistry 265 (9):5292-5295 (1990).
Nelson, P. H., et al., "Synthesis and Immunosuppressive Activity of Some Side-Chain Variants of Mycophenolic Acid," J. Med. Chem. 33:833-838 (1990).
Noto, T., et al., "A Turidimetric Bioassay Method For Determination Of Mycophenolic Acid," The Journal of Antibiotics XXIII (2):96-98 (1970).
Nowak, I., et al., "Mycophenolic Acid to Human Serum Albumin: Characterization and Relation to pharmacodynamics," Clinical Chemistry 41 (7):1011-1017 (1995).
Schutz, E., et al., "Identification of an Active Metabolite of Mycophenolic Acid in Plasma of Liver Transplant Recipients," Hepatology (in press, 1998).
Schutz, et al., "Therapeutic Drug Monitoring of Mycophenolic Acid: Comparison of HPLC and Immunoassay Reveals New MPA Metabolites," Transplantation Proceedings 30:1185-1187 (1998).
Schutz, E., et al., "Identification of a Pharmacology Active Metabolite of Mycophenolic Acid in Plasma of Transplant Recipients Treated with Mycophenolate Mofetil," Clinical Chemistry 45 (3):419-422 (1999).
Tett, S. E., et al., "Evaluation of an immunoassay for mycophenolic acid in plasma compared with a HPLC-UV assay," Clinical Chemistry 44(6):A96-A97 (1998).
Yatscoff, R. W., et al., "Pharmacodynamic monitoring of immunosuppressive drugs," Clinical Chemistry 44 (2):428-432 (1998).
Zimmermann, A. G., et al., "Characterization of the Human Inosine-5'-monophosphate Dehydrogenase Type II Gene," The Journal of Biological Chemistry 270 (12) 6808-6814 (1995).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Enzymatic measurement of mycophenolic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Enzymatic measurement of mycophenolic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enzymatic measurement of mycophenolic acid will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-579153

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.