Enzymatic hydrolysis of glycidate esters in the presence of bisu

Details Enzymatic hydrolysis of glycidate esters in the presence of bisu Enzymatic hydrolysis of glycidate esters in the presence of bisu

1989-02-10

1993-12-28

Rosen, Sam

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435135, 435136, 435155, 435132, C12P 762, C12P 740

Patent

active

052743004

ABSTRACT:
This invention relates to a method for the production of (2R,3S)-3-(4-methoxyphenyl)glycidic acids and esters thereof, which are synthetic intermediates for the production of the calcium antagonist diltiazem. The method involves the stereoselective enzymatic ester hydrolysis of racemic trans-3-(4-methoxyphenyl)glycidic acid ester to yield the resolved 2R,3S compound as the ester. Membrane reactor methods and apparatus for the conduct of this enzymatic resolution process are also disclosed herein, as is the use of bisulfite anion in the aqueous reaction phase as a means of minimizing the inhibitory effect of an aldehyde reaction by-product on the reaction's progress.

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