Enzymatic hydrolysis method for the preparation of C-13 hydroxyl

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435195, 435123, C12P 1702, C12N 914

Patent

active

057390169

ABSTRACT:
An enzymatic hydrolysis method for the preparation of compounds useful as intermediates in the preparation of taxanes such as taxol, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups.

REFERENCES:
patent: 4010072 (1977-03-01), Miura et al.
patent: 4017362 (1977-04-01), Miura et al.
patent: 4067774 (1978-01-01), Rubenstein et al.
patent: 4582639 (1986-04-01), Matson et al.
patent: 4599310 (1986-07-01), Matson et al.
patent: 4857653 (1989-08-01), Colin et al.
patent: 4924011 (1990-05-01), Denis et al.
patent: 4924012 (1990-05-01), Colin et al.
patent: 4985060 (1991-01-01), Higa
patent: 5202448 (1993-04-01), Carver et al.
A. L. Lehninger, Biochemistry, 2nd Edition, Worth Pub. Inc., 1975, p. 256.
H. Prauser, Bergy's Manual of Systematic Bacteriology, Genus Nocardioides Prauser 1976,61.sup.AL, vol. 4, 1989, pp. 2371-2375, S. T. Williams editor, Williams and Wilkins publ.
W. Boland, et al., Synthesis, "Esterolytic and Lipolytic Enzymes in Organic Synthesis", Dec., 1991, pp. 1049-1072.
E. Santaniello, et al., Chem. Rev., "The Biocatalytic Approach to the Preparation of Enantiomerically Pure Chiral Building Blocks", 1992, vol. 92, pp. 1071, 1094-1095.
I. Ringel et al., The Journal of Pharmacology and Experimental Therapeutics, "Taxol is Converted to 7-Epitaxol, a Biologically Active Isomer, in Cell Culture Medium", vol. 242, No. 2, pp. 692-698 (1987).
B. Monsarrat, et al., Drug Metabolism and Disposition, "Taxol Metabolism, Isolation and Identification of Three Major Metabolites of Taxol in Rat Bile", vol. 18, No. 6, pp. 895-901 (1990).
D. Kingston, Pharmac. Ther., "The Chemistry of Taxol", vol. 52, pp. 1-34, 1991.
G. Pedrocchi-Fantoni et al., J. Chem. Soc. Perkin Trans. 1, Regio- and Chemo-selective Properties of Lipase from Candida cylindracea, 1992, pp. 1029-1033.
V. S. Parmar, et al., Tetrahedron, "Regioselective Deacylation of Polyacetoxy Aryl-methyl Ketones by Lipases in Organic Solvents", vol. 48, No. 31, pp. 6495-6498, 1992.
M. Berger et al., Biotechnology Letters, "Regioselectivity of Lipases in Organic Solvents", vol. 13, No. 5, pp. 333-338 (1991).
R. Hanson et al., "Biotransformation of Taxus extracts with site-specific enzymes for hydrolysis of taxanes at C-10 and C-13", Biological Abstracts, xol. 97, 1994, Philadelphia, PA, US; abstract No. 206030, *abstract* 207th National Meeting of the American Chemical Society, San Diego, Mar. 13-17, 1994. Abstracts of Papers American Chemical Society 207 (1-2) 1994 Conference.
D. Cazzulino, et al., "Fermentation and Recovery of an Enzyme Used for Hydrolysis of Taxanes", Biological Abstracts, xol. 97, 1994, Philadelphia, PA, US; abstract No. 205977, *abstract* 207th National Meeting of the American Chemical Society, San Diego, Mar. 13-17, 1994. Abstracts of Papers American Chemical Society 207 (1-2) 1994 Conference.
Halarnkar, et al., "Formation of Cyclic Products from the Diepoxide of Long-Chain Fatty Esters by Cytosolic Epoxide Hydrolase", Archives of Biochemistry and Biophysics, vol. 294, No. 2, May 1, pp. 586-593, 1992.
Halarnkar, et al., "Catabolism of Epoxy Fatty Esters by the Purified Epoxide Hydrolase from Mouse and Human Liver", Archives of Biochemistry and Biophysics, vol. 272, No. 1, Jul., pp. 226-236, 1989.
Nourooz-Zadeh et al., "Characterization of the Cytosolic Epoxide Hydrolase-Catalyzed Hydration Products from 9,10:12,13-Diepoxy Stearic Esters", Archives of Biochemistry and Biophysics, vol. 294, No. 2, May 1, pp. 675-685, 1992.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Enzymatic hydrolysis method for the preparation of C-13 hydroxyl does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Enzymatic hydrolysis method for the preparation of C-13 hydroxyl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enzymatic hydrolysis method for the preparation of C-13 hydroxyl will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-633893

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.