Enzymatic hydrolysis and esterification processes for the prepar

Details Enzymatic hydrolysis and esterification processes for the prepar Enzymatic hydrolysis and esterification processes for the prepar

1992-04-29

1997-04-15

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

514365, 549292, C12P 740, A61K 31425

Patent

active

056208766

ABSTRACT:
Enzymatic hydrolysis and esterification processes for the preparation of compounds useful as HMG-CoA reductase inhibitors and/or as intermediates in the preparation of HMG-CoA reductase inhibitors.

REFERENCES:
patent: 3983140 (1976-09-01), Endo et al.
patent: 4346227 (1982-08-01), Terahara et al.
patent: 4444784 (1984-04-01), Hoffman et al.
Editor: Ebel "Biotechnology and Biotransformations" 1984 p. 48 148-164, 253-267.
Komagata et al., "Microbial Conversion of Compactin (ML-236B) to ML-236A", pp. 1574-1577, J. of Antibiotics, Nov. 1986.
Conder et al., abstract of Poster No. A2 titled "Discovery and Purification of an Esterase from Clonostachys Compactiuscula Useful for the Biotransformation of Lovastatin Acid to Triol Acid", presented at Biocatalysis for the 90s, An International Conference on the New Science and Techniques for the Discovery, Design and Use of Biocatalysts, Jun. 5-7, 1991, Lake Buena Vista, Florida.

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