Enzymatic detoxification of organophosphorus compounds

Details Enzymatic detoxification of organophosphorus compounds Enzymatic detoxification of organophosphorus compounds

1997-02-06

1999-07-27

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 691, 4352523, 4352625, 4353201, 536 232, C12N 916, C12N 1555, C12N 1570, B09B 300

Patent

active

059289279

ABSTRACT:
Compositions and methods are provided for enzymatic detoxification of organophosphorus compounds. The compositions contain a recombinant enzyme expressed by a cloned gene encoding an organophosphorus acid anhydrolase (OPAA-2) from the Alteromonas sp. bacteria, strain JD6.5. These compositions may be prepared as a dry powder and reconstituted with various water sources when needed. The methods involve application of compositions of recombinant OPAA-2 to surfaces or substances contaminated with organophosphorus compounds under conditions which maximize activity and stability of the enzyme.

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