Enzymatic detection of bacterial capsular polysaccharide antigen

Details Enzymatic detection of bacterial capsular polysaccharide antigen Enzymatic detection of bacterial capsular polysaccharide antigen

1985-01-31

1987-09-22

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 4, 435 29, 435200, 435810, C12N 924, C12Q 100, C12Q 134

Patent

active

046955410

ABSTRACT:
A substantially pure enzyme which hydrolyzes a polymer containing an .alpha. 2,8-linked N-acetyl neuraminic acid is obtained from K1-specific bateriophages and used for assays of bacterial polysaccharides in samples such as cerebrospinal fluid for testing for various disorders such as bacterial meningitis, septicemia, bacteremia, and the like. The enzyme may also be used therapeutically in treating such disorders by attacking cells which have an increased level of a polymer containing an .alpha. 2,8-linked N-acetyl neuraminic acid.

REFERENCES:
patent: 4071408 (1978-01-01), Flashner et al.
patent: 4316954 (1982-02-01), Snoke et al.

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