Enzymatic conversion of red cells for transfusion

Details Enzymatic conversion of red cells for transfusion Enzymatic conversion of red cells for transfusion

1981-08-13

1984-01-24

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 2, 424101, C12N 0500, A61K 3514, A01N 100

Patent

active

044277776

ABSTRACT:
Transfusable type O erythrocytes free of P1 antigenicity which are produced by an alpha-galactosidase conversion of type B antigen to type H antigen. The resulting erythrocytes retain a high level of ATP and 2,3 DPG.

REFERENCES:
patent: 4330619 (1981-08-01), Goldstein
Oishi et al., "Blood Group Substances-Degrading Enzymes Obtained from Streptomyces sp. Part IV Conversion of Human Blood Group B . . ." Agricultural and Biological Chemistry 40(1) (1976) p. 67-71.
Yates et al., "Linkage-Specific a-D-Galactosidases from Trichomon as Foetus, A Characterization of the Blood-Group B Destroying Enzyme." FEBS Letters 60(2) (1975) p. 281-285.
Harpaz et al., "A-D_14 Galactosidase from Soybeans Destroying Blood-Group B Antigens, Purification by Affinity Chromatography" European Journal of Biochemistry 77(2) (1977) p. 419-426.
Yatziv et al., "Action of A-Galactosidase on Glycoprotein from Human B-Erythrocytes." Biochemical and Biophysical Research Communications 45(2) (1971) p. 514-518.
Maintenance of 2,3-DPG and ATP Levels in Blood Stored for 30 Days at a Constant pH Obtained by Variation of CO.sub.2 VOX SANG 35: 184-192(1978) M. de Mendonca; M. Appel, J. Bidault, D. Masson-Pierre and E. Terrier.
Control of Hemoglobin Function within the Red Cell; The New England Journal of Medicine Jun. 18, 1970; pp. 1414-1421; Louis M. Sherwood, M.D., Editor, Edith E. Parris, Assistant Editor.
Reader's Digest -- Feb. 1982 News from the World of Medicine p. 139 "Changing Blood Types."
"Green Coffee Beans May Solve a Blood Bank Problem" JAMA, Jan. 1, 1982-vol. 247, No. 1-Medical News.
Associated Press-The Record, Oct. 29, 1981 "Enzyme Changes Blood of One Type to Another, Researchers Report".
Time-Nov. 16, 1981 "Capsules" "Transforming Blood".
Science "Group B Erythrocytes Enzymatically Converted to Group O Survive Normally in A, B, and O Individuals" Jan. 8, 1982, vol. 215, pp. 168-170.

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