Enzymatic cleavage of N-acyl-thienamycins

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C12D 1306

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041621930

ABSTRACT:
A method is disclosed for cleaving N-acyl-thienamycin compounds to yield thienamycin. The new method disclosed herein utilizes enzymes which are penicillin amidohydrolases to treat the starting compounds resulting in the antibiotic thienamycin.

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patent: 3945888 (1976-03-01), Takahashi et al.
patent: 3950357 (1976-04-01), Kahan et al.
patent: 3975235 (1976-08-01), Niwa et al.
Advances in Applied Microbiology, vol. 17, pp. 311-319 (1974).
Journal of Biochemistry, vol. 115, pp. 733-739 (1969).

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