Enzymatic acylation to afford .beta.-lactam antibiotics

Details Enzymatic acylation to afford .beta.-lactam antibiotics Enzymatic acylation to afford .beta.-lactam antibiotics

1976-05-12

1978-02-14

Shapiro, Lionel M.

Textiles: fiber preparation

195 36C, C12D 102

Patent

active

040736873

ABSTRACT:
Penicillin or cephalosporin antibiotics represented by following formula: ##STR1## where ##STR2## is an acyl group derived from an .alpha.-amino acid, N-ammonium salt of .alpha.-amino acid, or N--(C.sub.1 to C.sub.10) acyl-.alpha.-amino acid; COOM is carboxy or carboxylate salt group!
Are prepared by treating an amino compound selected from a group consisting of 6-aminopenicillanic acid, 7-aminocephalosporanic acid, 7-aminodeacetoxycephalosporanic acid, and their salts with an ester represented by following formula:

REFERENCES:
patent: 3761354 (1973-09-01), Abe et al.
patent: 3763000 (1973-10-01), Abe et al.
patent: 3816253 (1974-06-01), Takahashi et al.
patent: 3862004 (1975-01-01), Takahashi et al.
patent: 3962036 (1976-06-01), Liersch et al.

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