Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound having a 1-thia-5-aza-bicyclo
Patent
1994-02-03
1996-04-30
Naff, David M.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound having a 1-thia-5-aza-bicyclo
435 48, 435 49, 435 50, 435 51, 435196, 435197, 435198, 435839, 435911, 435917, C12P 3504, C12P 3506, C12N 920
Patent
active
055124542
ABSTRACT:
O-acylated cephalosporins are produced by reacting 3-hydroxymethylcephalosporins with an acyl donor containing at least three carbon atoms and an enzyme which is a Rodosporidium toruloides esterase, a wheat germ lipase, an Aspergillus niger lipase, an orange peel acetylesterase or a Bacillus subtilis esterase. A preferred enzyme is the esterase from Rodosporidium toruloides ATCC 10657. The enzyme can be used while in whole cells or in soluble or inmobilized form.
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Lowe David A.
Politino Michael
Romancik Guna
Usher John J.
Bristol--Myers Squibb Company
Lankford L. Blaine
Naff David M.
Savitsky Thomas R.
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