Entropic trapping and sieving of molecules

Details Entropic trapping and sieving of molecules Entropic trapping and sieving of molecules

2003-08-25

2008-09-23

Olsen, Kaj K (Department: 1795)

Chemistry: electrical and wave energy

Apparatus

Electrophoretic or electro-osmotic apparatus

C204S450000

Reexamination Certificate

active

07427343

ABSTRACT:
Nanofluidic entropic traps, comprising alternating thin and thick regions, sieve small molecules such as DNA or protein polymers and other molecules. The thick region is comparable or substantially larger than the molecule to be separated, while the thin region is substantially smaller than the size of the molecules to be separated. Due to the molecular size dependence of the entropic trapping effect, separation of molecules may be achieved. In addition, entropic traps are used to collect, trap and control many molecules in the nanofluidic channel. A fabrication method is disclosed to provide an efficient way to make nanofluidic constrictions in any fluidic devices.

REFERENCES:
patent: 5304487 (1994-04-01), Wilding et al.
patent: 5427663 (1995-06-01), Austin et al.
patent: 5599432 (1997-02-01), Manz et al.
patent: 5651900 (1997-07-01), Keller et al.
patent: 5707799 (1998-01-01), Hansmann et al.
patent: 5800690 (1998-09-01), Chow et al.
patent: 5837115 (1998-11-01), Austin et al.
patent: 5842787 (1998-12-01), Kopf-Sill et al.
patent: 5882465 (1999-03-01), McReynolds
patent: 5904824 (1999-05-01), Oh
patent: 5938923 (1999-08-01), Tu et al.
patent: 5948227 (1999-09-01), Dubrow
patent: 5958694 (1999-09-01), Nikiforov
patent: 6042710 (2000-03-01), Dubrow
patent: 6043080 (2000-03-01), Lipshutz et al.
patent: 6110339 (2000-08-01), Yager et al.
patent: 6156273 (2000-12-01), Regnier et al.
patent: 6186660 (2001-02-01), Kopf-Sill et al.
patent: 6193866 (2001-02-01), Bader et al.
patent: 6635163 (2003-10-01), Han et al.
patent: WO-98/54568 (1998-12-01), None
Chou, C., et al., “Sorting by Diffusion: An Asymmetric Obstacle Course for Continuous Molecular Separation”,PNAS,96 (24), (Nov. 23, 1999),pp. 13762-13765.
Nixon, G. I., et al., “Entropic Trapping and electrophoretic drift of a polyelectrolyte down a channel with a periodically oscillating width”,Physical Review E,53 (5), (May 1996),pp. 4969-4980.
Volkmuth, W. D., et al., “DNA electrophoresis in microlithographic arrays”,Nature,358, (Aug. 13, 1992),pp. 600-602.
Volkmuth, W. D., et al., “Trapping of branched DNA in microfabricated structures”,PNAS,92 (15), (Jul. 1995),pp. 6887-6891.

Affiliated with

Also associated with

Rating

Entropic trapping and sieving of molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Entropic trapping and sieving of molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Entropic trapping and sieving of molecules will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3965660