Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of storing cells in a viable state
Reexamination Certificate
2007-08-10
2010-11-23
Falk, Anne-Marie (Department: 1632)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of storing cells in a viable state
C435S375000, C435S377000, C435S382000, C435S395000
Reexamination Certificate
active
07838291
ABSTRACT:
The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.
REFERENCES:
patent: 2003/0119107 (2003-06-01), Dang et al.
patent: 2007/0186293 (2007-08-01), Teratani et al.
Dang et al. (2004) Controlled, scalable embryonic stem cell differentiation culture. Stem Cells 22: 275-282.
Weber et al. (2002) Formation of cartilage matrix proteins by BMP-transfected murine mesenchymal stem cells encapsulated in a novel class of alginates. Biomaterials 23: 2003-2013.
Conn Bryan
Rubin Albert L.
Smith Barry
Stenzel Kurt
Falk Anne-Marie
Fulbright & Jaworski LLP
The Rogosin Institute
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