Entrapment of nucleic acid sequencing template in sample mixture

Details Entrapment of nucleic acid sequencing template in sample mixture Entrapment of nucleic acid sequencing template in sample mixture

1995-11-08

1999-04-06

Tsang, Cecilia J.

Chemistry: electrical and wave energy

Processes and products

Electrophoresis or electro-osmosis processes and electrolyte...

204453, 204455, 204604, 935 19, C25B 700

Patent

active

058913130

ABSTRACT:
A capillary electrophoresis system and method of electrokinetically loading a capillary electrophoresis sample into a separation medium in a capillary tube in which an entangled polymer matrix is formed having the sample embedded therein. The matrix has a mesh size effective to retard movement of macromolecules such as DNA sequencing templates through the matrix when an electric field is applied across the matrix. The entangled polymer matrix is formed by a linear polymer having a molecular weight of at least 20K Daltons. Furthermore, the invention includes stable denaturants useful for the electrophoresis of nucleic acids.

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