Enterococcus faecalis polynucleotides encoding EF059

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S320100, C435S252300, C536S023700

Reexamination Certificate

active

06913907

ABSTRACT:
The present invention relates to novel genes fromE. faecalisand the polypeptides they encode. Also provided as are vectors, host cells, antibodies and methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists ofE. faecalispolypeptide activity. The invention additionally relates to diagnostic methods for detectingEnterococcusnucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Enterococcus.

REFERENCES:
patent: WO-00/068242 (2000-11-01), None
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Jazin et al, Regulatory Peptides 47:247-258, 1993.
Nallapareddy et al. “Diversity of ace, a gene encoding a microbial surface component recognizing adhesive matrix molecules, from different strains ofEnterococcus faecalisand evidence for production of ace during human infections”, Infection and Immunity 68(9):5210-5217 (2000).
NCBI Accession No. NP813955; “Role of mobile DNA in the evolution of vancomycin-resistantEnterococcus faecalis”, Science 299(5615):2071-2074 (2003) (Mar. 31, 2003).
Rich et al. “Ace is a collagen-binding MSCRAMM fromEnterococcus faecalis”, J. Biol. Chemistry 274(38):26939-26945 (1999).

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