Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-06-05
1986-12-23
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514336, 514312, 514314, 514333, 514397, 549267, 546268, 546156, 546168, 546256, C07D32300, C07D40512, A61K 31365
Patent
active
046312919
ABSTRACT:
There are provided novel enterobactin type compounds. There is provided a novel process for the production of enterobactin, and of novel enterobactin type compounds which process is based on the reaction of a serine derivative with a stannoxane of the [BU.sub.2 Sn(OCH.sub.2 CH.sub.2 O)] type. Enterobactin is a known compound of known utility. The novel derivatives are valuable as sequestering agents for iron and other transition metals, for the separation and analysis of same. They can be used as active ingredients in pharmaceutical compositions for the removal of such metals accumulated above an acceptable level in patients.
REFERENCES:
Rastetter et al., J. Org. Chem. 1980, 45(24) 5011-12; 1981, 46(18), 3579-3590.
Rogers CA. 93 188622b.
Pecoraro et al. CA. 99:32146n.
Corey et al., Tetrahedron Letters 45, 1977, 3919-3922.
Libman Jacqueline
Shanzer Abraham
Fan Jane T.
Yeda Research & Development Co. Limited
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