Enterically transmitted non-A/non-B hepatitis viral agent...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Reexamination Certificate

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Details

C424S228100, C530S300000, C530S350000, C530S324000, C530S325000, C530S326000, C530S327000, C530S328000, C435S235100

Reexamination Certificate

active

07094406

ABSTRACT:
Viral proteins derived from an enterically transmitted non-A
on-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in individuals infected with the viral hepatitis agent. This protein is useful in a diagnostic method for detecting infection by the enterically transmitted agent. Specific epitopes have been identified that are reactive with sera of individual infected with different strains of HEV. Also disclosed are DNA probes derived from a cloned sequence of the viral agent. These probes are useful for identifying and sequencing the entire viral agent and for assaying the presence of the viral agent in an infected sample, by using probe-specific amplification of virus-derived DNA fragments.

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