Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...
Patent
1995-06-07
1997-10-14
Mosher, Mary E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant virus encoding one or more heterologous proteins...
4242321, 424463, 424474, 424490, 424400, 4352351, A61K 3912, A61K 39245, A61K 948, A61K 900
Patent
active
056769504
ABSTRACT:
The subject invention pertains to a novel recombinant vaccinia virus vaccine for use in immunizing animals and humans against disease. The vaccine comprises a live vaccinia or replication deficient mutant vaccinia virus capable of expressing a single or multiple heterologous genes or gene fragments. In a preferred embodiment, the recombinant virus is contained in an orally-administered package that will only dissolve in the host animal's gut. The subject invention also pertains to a method of inducing a broad protective immune response through the oral administration of the recombinant vaccinia virus.
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Bender Bradley Stephen
Meitin Catherine Ann
Moss Bernard
Small, Jr. Parker A.
Mosher Mary E.
Salimi Ali R.
University of Florida
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