Enteric polymer coated capsule containing dried bacterial cultur

Details Enteric polymer coated capsule containing dried bacterial cultur Enteric polymer coated capsule containing dried bacterial cultur

1997-07-17

1999-12-28

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

424451, 424 9344, 424 9345, 424 9461, 435177, 435182, 435200, 4352529, 4352534, 435260, C12N 1100, C12N 924, C12N 104, A61K 3847

Patent

active

060080272

ABSTRACT:
A lactase-containing preparation is prepared for use by mammals having a lactase deficiency. A dried bacterial culture containing lactase is mixed with a desiccant such as silicon oxide to stabilize water content of the dried culture. A unit dosage of the resultant stabilized dried bacterial culture is encapsulated in an ingestible capsule such as gelatin capsule. The capsule is coated with an enteric polymer, and the coated capsule is treated under vacuum pressure to remove oxygen and moisture. The treated coated capsule has an extended shelf-life at room and elevated temperatures, and provides lactase activity for at least 10 hours after ingestion. The dried bacterial culture may be in freeze dried form. Suitable bacterial cultures are Lactobacillus acidophillus, Lactobacillus bulgaricus and Streptococcus thermophilus.

REFERENCES:
patent: 3629073 (1971-12-01), Cayle
patent: 3718739 (1973-02-01), Cayle
patent: 3860490 (1975-01-01), Guttag
patent: 4956295 (1990-09-01), Sudama
patent: 4983401 (1991-01-01), Eichel et al.
patent: 5478570 (1995-12-01), Sunohara et al.

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