Enteric formulations of physiologically active peptides and prot

Details Enteric formulations of physiologically active peptides and prot Enteric formulations of physiologically active peptides and prot

1992-05-26

1994-09-27

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424 851, 424464, 424472, 424477, 424484, 424501, 424502, 514 2, 514 11, 514 12, 514 19, A61K 3702

Patent

active

053507410

ABSTRACT:
An enteric formulation for a proteinous drug which protects it from enzymatic degradation and promotes its uptake by the intestinal tract when administered orally, comprises either a solid mass of an intimate mixture of the drug, a nontoxic nonionic surfactant, and an enteric material, or a solid mass of an intimate mixture of the drug with the nonionic surfactant covered by a discrete enteric coating.

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Takada et al., Chemical Abstracts, vol. 107, No. 6, Abstract No. 46298j, (Aug. 1987).
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Abstract of JA 5920219 (Feb. 1984).
Takada et al., CA 107: No. 6 (Dec. 1986).
O'Hagen et al., "Intestinal Absorption of Proteins, etc.", CRC Critical Reviews in Therapeutic Drug Carrier Systems, vol. 4, Issue 3, (1987), pp. 197-221.
Takada et al., "Enteric Solid Dispersion, etc.", Chem. Pharm. Bull., 37(2), 471-474 (Feb. 1989).

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