Enteric coated pharmaceutical compositions

Details Enteric coated pharmaceutical compositions Enteric coated pharmaceutical compositions

1991-09-30

1993-07-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424486, 424461, 424462, 424494, 424497, A61K 916

Patent

active

052252027

ABSTRACT:
An enteric coated pharmaceutical composition is provided which includes a medicament which is sensitive to a low pH environment of less than 3, such as pravastatin, which composition is preferably in the form of pellets which includes an enteric coating formed of neutralized hydroxypropylmethyl cellulose phthalate, plasticizer and anti-adherent. The so-coated pellets have good resistance to deterioration at pH less than 3 but have good drug release properties at greater than 3.

REFERENCES:
patent: 4017647 (1977-04-01), Ohno
patent: 4346227 (1982-08-01), Terahara
patent: 4524060 (1985-06-01), Mughal
patent: 4728512 (1988-03-01), Mehta
patent: 4794001 (1988-12-01), Mehta
patent: 4808413 (1989-02-01), Joshi
patent: 4857522 (1989-08-01), DiPietro
patent: 4994279 (1991-02-01), Aoki
patent: 5026559 (1991-06-01), Eichel
patent: 5026560 (1991-06-01), Makino
Stafford, J. W., Drug Dev. Ind. Pharm., 8(4), 513-530 (1982).
Bloor, J. R., et al., Drug Dev. Ind. Pharms., 15(14-16), 2227-2243 (1989).

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