Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1982-10-15
1985-06-25
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
424 19, 424 21, 424 35, 424 38, 514192, 514200, 514210, A61K 962, A61K 936, A61K 3143
Patent
active
045253390
ABSTRACT:
There is presented a method, in the form of a dosage formulation, for transforming substantially orally inactive .beta.-lactam antibiotics or their pharmaceutically acceptable salts or the esters, ethers, or hydrates of said antibiotics or their salts into orally active compounds by combination of the chosen .beta.-lactam antibiotic with an enhancer comprising an aliphatic, preferably a C.sub.2 to C.sub.18, straight- or branched-chain, saturated or unsaturated, fatty acid or an aliphatic, preferably a C.sub.2 to C.sub.12, straight- or branched-chain, saturated or unsaturated, fatty acid mono-, di- or triglyceride or mixtures thereof, partial or total esters of propylene glycol, polyethylene glycol and carbohydrates of C.sub.2 to C.sub.12 fatty acids, as well as the pharmaceutically acceptable esters and ethers of said glycerides. The antibiotic and enhancer mixture may be administered orally as a solid dosage form with the .beta.-lactam antibiotic above or, optionally, with the enhancer protected by an enteric coating.
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Behl Charanjit
Beskid George
Shah Navnit
Tossounian Jacques
Unowsky Joel
Hoffman Frank P.
Hoffmann-La Roche Inc.
Leon Bernard S.
Rose Shep K.
Saxe Jon S.
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