Enteral contrast medium useful for nuclear magnetic resonance im

Details Enteral contrast medium useful for nuclear magnetic resonance im Enteral contrast medium useful for nuclear magnetic resonance im

1986-12-29

1988-01-12

Warden, Robert J.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

436806, 128653, 128654, A61K 4900, A61B 505, A61B 600

Patent

active

047190981

ABSTRACT:
An enteral contrast medium useful for proton nuclear spin tomography contains at least one physiologically compatible paramagnetic compound in combination with a physiologically compatible, osmotically active substance, as well as a physiologically compatible base/buffer or buffer mixture with a pH value of 3 to 8, and, optionally, also a viscosity-raising material, all dissolved or suspended in water. It is excellently suitable for enhancing contrast in imaging, e.g., of the gastrointestinal tract by nuclear spin tomography.

REFERENCES:
patent: 3832457 (1974-08-01), Sugimoto et al.
patent: 4615879 (1986-10-01), Runge et al.
France Patent, Brevet Special de Medicament, No. 4,679M, Radioscopic Contrast Agent, 01/23/1967.
Runge et al., Radiology, vol. 147, (1983), pp. 789-791.
The Merck Index, 9th Edition, (1976), p. 789, No. 5915.
Rayudu, G., Radiotracers for Medical Applications, vol. 1, (1983), p. 148, 176.
Biological Abstracts, Band 78, Nr., 3, 1984, Seite 2515, Zusammenfassung Nr. 22904; R. Grossman et al.: "Gadolinium enhanced NMR Images of Experimental Brain Abscess", & J. Comput. Assist. Tomogr. 8(2):204-207, 1984.
Chemical Abstracts, Band 99, Nr. 7, 15. Aug. 1983, Seite 232, Zusammenfassung Nr. 49843k, Columbus Ohio, US; V. M. Runge et al.: "Work in Progress: Potential Oral and Intravenous Paramagnetic NMR Contrast Agents", & Radiology (Easton, Pa.) 1983, 147(3), 798-791.

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