Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Separation or purification
Reexamination Certificate
2006-05-02
2006-05-02
Minnifield, Nita (Department: 1645)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Separation or purification
C530S350000, C435S069100, C424S184100, C424S234100
Reexamination Certificate
active
07038012
ABSTRACT:
The invention relates to a process for enriching the presence ofH. pyloriNAP in a mixture of proteins. The process involves salting-out other proteins. NAP has been found to remain soluble at ammonium sulphate concentrations of 80% and above. The process may involve the additional step of metal chelate chromatography. The combination of salting-out and metal chelate chromatography results in very pure NAP. The NAP may have the same sequence as NAP naturally occurring inH. pyloriand is free from sequences typically associated with recombinant protein production. The processes and NAP of the invention can be used in diagnostic and therapeutic products and processes.
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Chiron SRL
Groth Felicity E.
Hale Rebecca M.
Harbin Alisa A.
Minnifield Nita
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