Enrichment for a thymocyte subset having progenitor cell activit

Details Enrichment for a thymocyte subset having progenitor cell activit Enrichment for a thymocyte subset having progenitor cell activit

1995-04-07

1998-10-13

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 724, 424 9371, 4241401, 4241431, 4241541, 53038875, C12N 1585, G01N 3353, A61K 39395

Patent

active

058211080

ABSTRACT:
A subpopulation in the CD4.sup.+ 8.sup.+ (DP) thymic blast population is identified that is the precursor for thymic T cells. All such progenitors are c-kit.sup.+. The c-kit.sup.+ subset expresses lower levels of CD4 and CD8 than the large and small DP c-kit- cells. These DP.sup.int c-kit.sup.+ cells differentiate to thymic T cells rapidly on heterogenous thymic stromal cell cultures. Similar maturation takes place in vivo over 4 days. A method for isolating the cells which are c-kit.sup.+ and which express intermediate or low levels of CD4+/CD8+ is also disclosed.

REFERENCES:
Majundar et al. 1990 J. Immnology vol. 144, No. 1, :111-121.
Ashman et al. 1991 Blood vol. 78, No. 1, 30-37.
Adkins et al. (1987) Ann. Rev. Immunol. 5:323.
Besmer et al. (1986) Nature 320:415-421.
Chabot et al. (1988) Nature 335:88-89.
Chan et al. (1994) Semin Immunol 6:241-248.
Fowlkes and Pardoll (1989) Adv. Immunol. 44:207.
Guidos et al. (1990) J. Exp. Med. 172:835-845.
Ikuta and Weissman (1992) P.N.A.S. 89:1502-1506.
Kraft et al. (1993) J.E.M. 178:265-277.
Moore et al. (1994) Immunology 81:115-119.
Morrissey et al. (1994) Cell Immunol 157:118-131.
Okada et al. (1991) Blood 78:1706-1712.
Terstappen et al. (1992) Blood 79:666.
Veis et al. (1993) J. Immunol 151:2546-2554.
Wolf and Cohen (1992) Immunology 77:362-368.
Wu et al. (1991) Nature 349:371.
Tatsumi et al. (1990) P.N.A.S. 87:2750-2754.
Denning et al. (1989) J. Immunol. 142:2988-2997.

Affiliated with

Also associated with

Rating

Enrichment for a thymocyte subset having progenitor cell activit does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Enrichment for a thymocyte subset having progenitor cell activit, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enrichment for a thymocyte subset having progenitor cell activit will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-312574