Organic compounds -- part of the class 532-570 series – Organic compounds – Silicon containing
Patent
1988-05-31
1991-10-29
Shaver, Paul F.
Organic compounds -- part of the class 532-570 series
Organic compounds
Silicon containing
556418, 556436, 556437, 556446, 556470, C07F 710, C07F 718
Patent
active
050618172
ABSTRACT:
The present invention relates to .beta.-lactam compound having the formula (I): ##STR1## wherein R.sup.1 is a trialkylsilyl group, dimethyl-1,1,2-trimethylpropylsilyl group, acetyl group, benzyloxycarbonyl group, O-nitrobenzyloxycarbonyl group, p-nitrobenzyloxycarbonyl group or t-butyl group, R.sup.2, R.sup.3 and R.sup.4 are a member selected from the group consisting of a lower alkyl group having 1 to 6 carbon atoms, phenyl group and an aralkyl group and a process for preparing the compound which comprises reacting enolsilylethers having the formula (III): ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as above, with chlorosulfonylisocyanate and then reducing the obtained product. The .beta.-lactam compound of the present invention is a useful intermediate for preparing carbapenem .beta.-lactam compound.
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Kan Kazunori
Miyama Akimasa
Ohashi Takeisa
Sada Isao
Ueyama Noboru
Kanegafuchi Kagaku Kogyo & Kabushiki Kaisha
Shaver Paul F.
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