Enlarged-hetero-ring prostacylin analogs

Details Enlarged-hetero-ring prostacylin analogs Enlarged-hetero-ring prostacylin analogs

1978-08-21

1979-12-11

Chan, Nicky

Harness for working animal

C07D31102

Patent

active

041784413

ABSTRACT:
Prostaglandin (PG.sub.1) derivatives having (1) a 6-keto feature, together with a 9-deoxy-9-hydroxymethyl feature for example ##STR1## or (2) a 9-deoxy-6,9-epoxymethano feature together with a 5-halo or 6-hydroxy feature, for example ##STR2## or a 5,6-didehydro feature, for example in an enol ether of the formula. ##STR3## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.

REFERENCES:
Pace-Asciak et al., Biochem., 10, 3657 (1971).
Pace-Asciak et al., Jacs., 98, 2348 (1976).

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