Enlarged-hetero-ring prostacyclin analogs with 5-halo feature

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2603452, 542429, C07D31102

Patent

active

042152143

ABSTRACT:
Prostaglandin (PG.sub.1) derivatives having (1) a 6-keto feature, together with a 9-deoxy-9-hydroxymethyl feature for example ##STR1## or (2) a 9-deoxy-6,9-epoxymethano feature together with a 5-halo or 6-hydroxy feature, for example ##STR2## or a 5,6-didehydro feature, for example in an enol ether of the formula ##STR3## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.

REFERENCES:
patent: 4150222 (1979-04-01), Johnson

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