Enlarged-hetero-ring prostacyclin analogs

Details Enlarged-hetero-ring prostacyclin analogs Enlarged-hetero-ring prostacyclin analogs

1977-07-28

1978-11-07

Chan, Nicky

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

542426, 542439, 542441, 542447, 424283, C07D31102, A61K 3135

Patent

active

041245997

ABSTRACT:
Prostaglandin (PG.sub.1) derivatives having (1) a 6-keto feature, together with a 9-deoxy-9-hydroxymethyl feature for example ##STR1## or (2) a 9-deoxy-6,9-epoxymethano feature together with a 5-halo or 6-hydroxy feature, for example ##STR2## or a 5,6-didehydro feature, for example in an enol ether of the formula ##STR3## said derivatives having pharmacological activity. Processess for preparing them and the appropriate intermediates are disclosed.

REFERENCES:
pace-Asciak et al., Biochem., 10, 3657 (1971).
Pace-Asciak et al., Jacs., 98, 2348 (1976).

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