Enkephalinase enzyme inhibiting compounds

Details Enkephalinase enzyme inhibiting compounds Enkephalinase enzyme inhibiting compounds

1981-05-18

1982-05-11

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

424319, 424324, 564162, C07C14941

Patent

active

043294952

ABSTRACT:
Chiral 2-(2-benzyl-3-mercaptopropionylamino)-1-alkanol derivatives and chiral 2-(2-benzyl-3-mercaptopropionylamino)-4-methylthiobutyric acids are inhibitors of enkephalinase enzyme, reflecting their clinical utility as analgesics or anticonvulsant agents, or as therapy for disorders in which endogenous enkephalin levels are below normal.

REFERENCES:
patent: 4046889 (1977-09-01), Ondetti et al.
Rogues et al., Nature 288,286 (1980).

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