Enkephalinase B inhibitors, their preparation, and pharmaceutica

Details Enkephalinase B inhibitors, their preparation, and pharmaceutica Enkephalinase B inhibitors, their preparation, and pharmaceutica

1985-10-01

1989-02-14

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548537, 435121, A61K 3140, C07D20709

Patent

active

048046760

ABSTRACT:
Propioxatins A and B, which have the formula: ##STR1## wherein R represents a hydrogen atom or a methyl group, can be prepared by cultivating a suitable strain of Kitasatosporia, e.g. Kitasatosporia sp. SANK 60684 (FERM-P 7581). They can be salified to give pharmaceutically acceptable salts. The compounds are active as enkephalinase B inhibitors and are thus capable of enhancing enkephalin activity in vivo.

REFERENCES:
patent: 4284561 (1981-08-01), Petrillo, Jr. et al.
patent: 4663342 (1987-05-01), Umezawa et al.

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