Enkephalinase and endorphinase inhibitors as anti-craving compos

Details Enkephalinase and endorphinase inhibitors as anti-craving compos Enkephalinase and endorphinase inhibitors as anti-craving compos

1985-07-22

1988-08-02

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

A61K 31195

Patent

active

047614293

ABSTRACT:
A new class of anti-craving compositions is provided by substances which inhibit breakdown of endogenous substances such as enkephalins and/or endorphins. An anti-alcohol craving effect is observed with an enkephalin breakdown inhibitor. Specifically, D-phenylalanine, DL-phenylalanine, D-leucine, DL-leucine, and hydrocinnamic acid, each an encephalin breakdown inhibitor, significantly lowered alcohol intake in animals and humans. The anti-alcohol desire effect is observed in animals genetically prone to choose alcohol over water solutions.

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patent: 4439452 (1984-03-01), Ehrenpreis
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