Enkephalin derivatives

Details Enkephalin derivatives Enkephalin derivatives

1978-06-05

1980-07-22

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, A61K 3700, C07C10352

Patent

active

042139686

ABSTRACT:
Improved enkephalin derivatives represented by the formula: ##STR1## wherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-norvaline, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-aspartic acid, D-asparagine, D-lysine, D-proline, D-histidine and D-arginine; Y is a residue of methionine or leucine and Z is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and loweralkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel pentapeptides and pharmaceutical compositions and methods employing them.

REFERENCES:
patent: 4092304 (1978-05-01), Jones, Jr. et al.
C. Pert, et al., Opiates and Endogenous Opioid Peptides 1976 pp. 79-86.
Coy et al., Biochem. and Biophys. Res. Comm. 73, 1976 pp. 632-638.
C. Pert, et al., Science 194 pp. 330-332 (1976).

Affiliated with

Also associated with

Rating

Enkephalin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Enkephalin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enkephalin derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2178331