Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-06-26
1994-07-05
Cashion, Jr., Merrell C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 9, 514 11, 530317, 530330, A61K 3702, C07K 512, C07K 706
Patent
active
053267516
ABSTRACT:
A new class of opioid receptor analogs is described based on an alanine substitution in the three position in the enkephalin analog DPDPE. The alanine-substituted analogs show increased selectivity for the delta type of opioid receptors over the mu type of receptors.
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Clark, J. A., et al., "[D-Pen.sup.2, D-Pen.sup.5 ]enkephalin (DPDPE): A .delta.-selective Enkephalin with Low Affinity for .mu.1 Opiate Binding Sites," E. J. Pharm. 128:303-304 (1986).
Haaseth, R. C. et al., "Potent and Selective 3-position Analogs of DPDPE," INRC/CPDD Meeting Jun. 20-27, 1992 (Poster presented Jun. 27).
Misika, A. et al., "Computer Modeling of Opioid Selective Ligands: Possible New Topographical Relationships to Bioactivity are Examined with New Analogs Designed for .delta. Opioid Receptor," Peptides (J. Smith and J. Rivier Eds., Escom. 1991).
Haaseth Ronald C.
Hruby Victor J.
Arizona Board of Regents on Behalf of the University of Arizona
Cashion Jr. Merrell C.
Marshall S. G.
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