Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1972-11-06
1979-12-04
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424240, 424241, 424242, 424243, 424337, A61K 3110, A61K 3740
Patent
active
041772679
ABSTRACT:
A method of enhancing tissue penetration of physiologically active steroidal agents by conjointly applying them to the tissue with dimethyl sulfoxide. Penetration of the skin and the mucous membranes of the body cavities by these agents may be enhanced by conjoint application of such agents and dimethyl sulfoxide directly to such membranes. Preferably, for penetration of these agents through the skin compositions of DMSO at concentrations of 50% and above are employed and for penetration through mucous membranes, compositions including DMSO at concentrations of 10% and above are employed. Steroidal agents may be advantageously administered by injection with DMSO in concentrations preferably up to 20% by weight to enhance penetration of internal tissue membrane barriers to achieve better distribution of these agents.
REFERENCES:
patent: 2942008 (1960-06-01), Lubowe
Faust, American Perfumer 77(1); 23-26, Jan. 1962, "Some New Components for Cosmetic and Dermatologic Vehicles".
Marson, Boll. Chimicofarm 102:109-124, Feb. 1963, "Dimethylsulfoxide, A Water-Mimotic Solvent".
Brown et al., J. Pharm. Pharmacol. 15:688-692, Oct. 1963, A Note on the Toxicity and Solvent Properties of Dimethyl Sulphoxide.
Stoughton et al., "Archives of Dermatology," vol. 90, pp. 512-517, Nov. 1964.
Stoughton, "Archives of Dermatology," vol. 91, No. 6, pp. 657-660, Jun. 1965.
Kligman, "Journal of the American Medical Association", 193(10), pp. 796-804; (11), pp. 923-928, Sep. 1965.
Crown Zellerbach
Horton Corwin R.
Rose Shep K.
Teigland Stanley M.
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